SrasV1, Main, Exploration, bibRecord, 002F27

Investigation of the pharmacophore space of Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) NTPase/helicase by dihydroxychromone derivatives

Identifieur interne : 002F27 ( Main/Exploration ); précédent : 002F26; suivant : 002F28

Investigation of the pharmacophore space of Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) NTPase/helicase by dihydroxychromone derivatives

Auteurs : Chaewoon Lee [Corée du Sud] ; JIN MOO LEE [Corée du Sud] ; Na-Ra Lee [Corée du Sud] ; Dong-Eun Kim [Corée du Sud] ; Yong-Joo Jeong [Corée du Sud] ; Youhoon Chong [Corée du Sud]

Source :

Bioorganic & medicinal chemistry letters : (Print) [ 0960-894X ] ; 2009.

RBID : Pascal:09-0451246

Descripteurs français

Pascal (Inist)
- Modélisation, Virus syndrome respiratoire aigu sévère, Nucleoside-triphosphatase, Syndrome respiratoire aigu sévère, Dérivé de la chromone, Inhibiteur, Activité biologique, In vitro, Synthèse chimique, Cétol, Phénols, Déroulement, DNA, Changement conformation, Chromone(7-arylméthoxy-3,5-dihydroxy-2-[3,4-dihydroxyphényl]), 1-Benzopyrane dérivé.

English descriptors

KwdEn :
- Biological activity, Chemical synthesis, Chromone derivatives, Conformational changes, DNA, In vitro, Inhibitor, Ketol, Modeling, Nucleoside-triphosphatase, Phenols, Severe acute respiratory syndrome, Severe acute respiratory syndrome virus, Unwinding.

Abstract

Aryl diketoacids have been identified as the first SARS-CoV NTPase/helicase inhibitors with a distinct pharmacophore featuring an arylmethyl group attached to a diketoacid. In order to search for the pharmacophore space around the diketoacid core, three classes of dihydroxychromone derivatives were prepared. Based on SAR study, an extended feature of the pharmacophore model of SARS-CoV NTPase/ helicase was proposed which is constituted of a diketoacid core, a hydrophobic arylmethyl substituent, and a free catechol unit.

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Aryl diketoacids have been identified as the first SARS-CoV NTPase/helicase inhibitors with a distinct pharmacophore featuring an arylmethyl group attached to a diketoacid. In order to search for the pharmacophore space around the diketoacid core, three classes of dihydroxychromone derivatives were prepared. Based on SAR study, an extended feature of the pharmacophore model of SARS-CoV NTPase/ helicase was proposed which is constituted of a diketoacid core, a hydrophobic arylmethyl substituent, and a free catechol unit.</div>
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Investigation of the pharmacophore space of Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) NTPase/helicase by dihydroxychromone derivatives

Investigation of the pharmacophore space of Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) NTPase/helicase by dihydroxychromone derivatives

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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